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Results for "

anxiety disorders

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (13) Adrenergic Receptor (3) CRFR (1) Cytochrome P450 (1) GABA Receptor (3) Glyoxalase (GLO) (1) Histamine Receptor (5) iGluR (1) Isotope-Labeled Compounds (3) MCHR1 (GPR24) (1) mGluR (1) nAChR (2) Neuropeptide Y Receptor (1) Opioid Receptor (1) Orexin Receptor (OX Receptor) (4) Oxytocin Receptor (2) P2X Receptor (1) Serotonin Transporter (6) Sigma Receptor (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (2) Endocrinology (8) Inflammation/Immunology (5) Metabolic Disease (1) Neurological Disease (40)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-105858

BNC210 H-Ile-Trp-OH; IW-2143	nAChR	Neurological Disease
BNC210 (H-Ile-Trp-OH) is an orally active α7 nAChR negative alteration modulator (NAM) with no apparent side effects. BNC210 exhibits acute anxiolytic activity in rodent models of anxiety. BNC210 can be used in studies of generalised anxiety disorders .

HY-B0161A

Duloxetine hydrochloride 4 Publications Verification (S)-Duloxetine hydrochloride; LY-248686 hydrochloride	Serotonin Transporter	Neurological Disease
Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a K_i of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .

HY-B0161

Duloxetine (S)-Duloxetine; LY248686	Serotonin Transporter	Neurological Disease
Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a K_i of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .

HY-110029

Paroxetine maleate BRL29060 maleate	Serotonin Transporter	Neurological Disease
Paroxetine maleate is a potent and selective inhibitor of SSRI. Paroxetine maleate is used in generalized anxiety disorder, post traumatic stress disorder, premenstrual dysphoric disorder and chronic headache research .

HY-14225

BMS-764459	CRFR Cytochrome P450	Neurological Disease
BMS-764459 is a CRF1 antagonist. BMS-764459 can be used for the research of neurological disorders such as depression and anxiety. BMS-764459 is also an atypical CYP1A1 inducer .

HY-B0161AS

Duloxetine D3 hydrochloride (S)-Duloxetine-d₃ (hydrochloride); LY248686-d₃ (hydrochloride)	Serotonin Transporter	Neurological Disease
Duloxetine-d₃ (hydrochloride) is a deuterium labeled Duloxetine hydrochloride. Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD)[1][2].

HY-103518A

CGP36216 hydrochloride	GABA Receptor	Neurological Disease
CGP36216 hydrochloride is a selective antagonist at GABA presynaptic receptor. CGP36216 binds to GABAB receptor with a K_i value of 0.3 μM. CGP36216 hydrochloride can be used for research of anxiety and trauma-related disorders .

HY-116076

S-15535	5-HT Receptor	Neurological Disease
S-15535 is a highly selective 5-HT_1A receptor ligand. S-15535 is an antagonist of postsynaptic 5-HT_1A receptors and an agonist of presynaptic 5-HT_1A receptors. S-15535 can be used in research on psychiatric disorders, such as anti-anxiety .

HY-153458

Orexin receptor modulator-1	Orexin Receptor (OX Receptor)	Neurological Disease Metabolic Disease
Orexin receptor modulator-1 is an orexin receptor modulator. Orexin receptor modulator-1 can be used for the research of substance addiction, panic disorder, anxiety, post-traumatic stress disorder, pain, depression, seasonal affective disorder, an eating disorder, or hypertension .

HY-147306

ZLc-002	Others	Neurological Disease
ZLc-002 is a selective inhibitor of nNOS-Capon coupling. ZLc-002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain. ZLc-002 can be used for the research of anxiety disorder and inflammation .

HY-B0548

Hydroxyzine	Histamine Receptor	Inflammation/Immunology Endocrinology
Hydroxyzine, a benzodiazepine antihistamine agent, acts as an orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine has anxiolytic effect and can be used for the research of generalised anxiety disorder .

HY-B0548A

Hydroxyzine dihydrochloride	Histamine Receptor	Inflammation/Immunology Endocrinology
Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder .

HY-148325

α7 Nicotinic receptor agonist-1	nAChR	Neurological Disease
α7 Nicotinic receptor agonist-1 (Preparation 5) is an α7 nAChR agonist. α7 Nicotinic receptor agonist-1 can be used in studies of psychiatric disorders (such as schizophrenia, manic or hypomanic depression and anxiety disorders) and intellectual disorders (such as alzheimer's disease, learning deficits, cognitive deficits, attention deficits, memory loss, lewy body dementia and attention deficit hyperactivity disorder) .

HY-15522

WAY-267464	Oxytocin Receptor	Neurological Disease
WAY-267464 is a non-peptide oxytocin receptor (OTR) agonist. WAY-267464 can impair social recognition memory in rats through a vasopressin 1A receptor antagonist action. WAY-267464 can be used for the research of psychiatric disorders, such disorders include autism spectrum disorder, schizophrenia, and social anxiety disorder .

HY-118901

Opipramol Ensidon; G-33040	Sigma Receptor	Neurological Disease
Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a K_i value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD) .

HY-134188

JNJ-54717793	Orexin Receptor (OX Receptor)	Neurological Disease
JNJ-54717793, as a brain penetrant, is an orally active, selective and high affinity orexin-1 receptor (OX1R) antagonist (plasma EC₅₀=85 ng/mL). The K_i values of JNJ-54717793 for hOX1R (human OX1R) and hOX2R are 16 nM and 700 nM, respectively. JNJ-54717793 is a potent compound of anxiety disorders .

HY-122487

Troriluzole BHV-4157	Others	Neurological Disease
Troriluzole, a third-generation, tripeptide proagent of Riluzole (HY-B0211), is an orally active glutamate modulator. Troriluzole reduces synaptic glutamate level and increases the synaptic glutamate absorption. Troriluzole has the potential for Alzheimer disease and generalized anxiety disorder (GAD) .

HY-107624

ATC0175	MCHR1 (GPR24)	Neurological Disease
ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC₅₀s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders .

HY-B0193

Prazosin Maximum Cited Publications 8 Publications Verification	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder.

HY-19872

AZD-6280

GABA Receptor Neurological Disease

AZD-6280 is a selective GABAA(α2/3) receptor modulator, used for treatment of generalized anxiety disorder.

AZD-6280	GABA Receptor	Neurological Disease
AZD-6280 is a selective GABAA(α2/3) receptor modulator, used for treatment of generalized anxiety disorder.

HY-B1115S

Buspirone-d8 hydrochloride	Isotope-Labeled Compounds 5-HT Receptor	Neurological Disease
Buspirone-d₈ (hydrochloride) is the deuterium labeled Buspirone hydrochloride. Buspirone hydrochloride is an anxiolytic psychotropic agent, is used to treat generalized anxiety disorder (GAD).

HY-108679

WAY-267464 hydrochloride	Oxytocin Receptor	Neurological Disease
WAY-267464 hydrochloride is a non-peptide oxytocin receptor (OTR) agonist. WAY-267464 hydrochloride can impair social recognition memory in rats through a vasopressin 1A receptor antagonist action. WAY-267464 hydrochloride can be used for the research of psychiatric disorders, such disorders include autism spectrum disorder, schizophrenia, and social anxiety disorder .

HY-B0161S

Duloxetine-d7	Isotope-Labeled Compounds Serotonin Transporter	Neurological Disease
Duloxetine-d₇ ((S)-Duloxetine-d₇) is the deuterium labeled Duloxetine. Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD)[1][2].

HY-B0161AR

Duloxetine hydrochloride (Standard) (S)-Duloxetine hydrochloride (Standard); LY-248686 hydrochloride (Standard)	Serotonin Transporter	Neurological Disease Cancer
Duloxetine (hydrochloride) (Standard) is the analytical standard of Duloxetine (hydrochloride). This product is intended for research and analytical applications. Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a K_i of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .

HY-109164

Zelquistinel AGN-241751; GATE-251	iGluR	Neurological Disease
Zelquistinel (AGN-241751) is a N-methyl-D-aspartate (NMDA) receptor partial agonist used for the research of depression, anxiety and other related psychiatric disorders .

HY-B0193S

Prazosin-d8	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Prazosin-d₈ is the deuterium labeled Prazosin. Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder.

HY-148718

4-Chloro Trazodone hydrochloride	Others	Neurological Disease
4-Chloro Trazodone hydrochloride is an isomer of Trazodone hydrochloride (HY-B0478). Trazodone hydrochloride is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders .

HY-10886

MCOPPB	Opioid Receptor	Neurological Disease
MCOPPB is an orally active and selective agonist of Nociceptin/Orphanin FQ–Receptor. MCOPPB inhibits signaling through the NOP receptor in the mouse brain. MCOPPB is used in anxiety disorders research .

HY-B0548AS2

Hydroxyzine-d8 dihydrochloride	Isotope-Labeled Compounds Histamine Receptor	Inflammation/Immunology Endocrinology
Hydroxyzine-d₈ (dihydrochloride) is the deuterium labeled Hydroxyzine dihydrochloride. Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder[1][2].

HY-B0548AS1

Hydroxyzine-d4' dihydrochloride Vistaril-d4' dihydrochloride; Atarax-d4' dihydrochloride
Hydroxyzine-d₄ (dihydrochloride) is the deuterium labeled Hydroxyzine dihydrochloride. Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder[1][2].

HY-B0478R

Trazodone hydrochloride (Standard) AF-1161 (Standard)	5-HT Receptor	Neurological Disease
Trazodone (hydrochloride) (Standard) is the analytical standard of Trazodone (hydrochloride). This product is intended for research and analytical applications. Trazodone (hydrochloride) (AF-1161) is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders.

HY-B1115A

Buspirone 1 Publications Verification
Buspirone is an orally active 5-HT1A receptor agonist, and a dopamine D2 autoreceptorsant antagonist. Buspirone is an anxiolytic agent, and can be used for the generalized anxiety disorder research .

HY-103518

CGP36216	GABA Receptor	Neurological Disease
CGP36216 is a selective antagonist at GABA presynaptic receptor. CGP36216 binds to GABAB receptor with a K_i value of 0.3 μM. CGP36216 hydrochloride can be used for research of anxiety and trauma-related disorders .

HY-19490

VQW-765 AQW-051
VQW-765 (AQW-051) is a selective and orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonist with a pK_D value of 7.56 to recombinantly expressed human α7-nAChR. VQW-765 shows anxiolytic-like effect in vivo. VQW-765 can be used for the research of anxiety disorder and acute performance anxiety .

HY-18941B

(rel)-Eglumegad (rel)-LY354740; (rel)-Eglumetad	mGluR	Neurological Disease
(rel)-Eglumegad ((rel)-LY354740) is a relative configuration of Eglumegad (HY-18941). Eglumegad is a highly potent and selective group II (mGlu2/3) receptor agonist with EC₅₀s of 5 and 24 nM for transfected human mGlu2 and mGlu3 receptors, respectively .

HY-122422

Gepirone	5-HT Receptor	Others
Gepirone is a selective and affinitive 5-HT_1A agonist. Gepirone binds selectively to 5-HT_1A receptor binding site. Gepirone acts as an antidepressant agent can be used for anxiety and major depressive disorder research .

HY-B0548AR

Hydroxyzine dihydrochloride (Standard)	Histamine Receptor	Inflammation/Immunology Endocrinology
Hydroxyzine (dihydrochloride) (Standard) is the analytical standard of Hydroxyzine (dihydrochloride). This product is intended for research and analytical applications. Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder .

HY-101834

ACT-462206	Orexin Receptor (OX Receptor)	Others
ACT-462206 is an orally active and potent dual Orexin 1/Orexin 2 receptor antagonist with IC₅₀s of 60 nM (Orexin 1) and 11 nM (Orexin 2), respectively. ACT-462206 exhibits brain penetration properties, and can be used for insomnia, stress/anxiety-related disorders and addiction research .

HY-136684

BrBzGCp2 S-p-Bromobenzylglutathione cyclopentyl diester	Glyoxalase (GLO)	Neurological Disease Cancer
BrBzGCp2 is a Glyoxalase 1 (GLO1) inhibitor, with a GC₅₀ of 4.23 μM in HL-60 cells. BrBzGCp2 possesses antitumor and neuroprotective activity .

HY-108626

ML154 NCGC84	Neuropeptide Y Receptor	Neurological Disease
ML154 (NCGC84) is a selective, brain-penetrant and non-peptide neuropeptide S receptor (NPSR) antagonist with a pA₂ of 9.98. ML154 potently inhibits NPS-stimulated cellular calcium, cAMP, and ERK phosphorylation responses with IC₅₀ values of 36.5 nM, 22.1 nM, and 9.3 nM, respectively .

HY-120738

p-MPPI hydrochloride 1 Publications Verification	5-HT Receptor	Neurological Disease
p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects .

HY-A0095

Flibanserin 2 Publications Verification BIMT-17; BIMT-17BS	5-HT Receptor	Neurological Disease Cancer
Flibanserin (BIMT-17; BIMT-17BS) is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with K_i values of 1 nM and 49 nM, respectively. Flibanserin binds to dopamine D4 receptors with an K_i value of 4-24 nM. Flibanserin shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research ^- .

HY-A0095A

Flibanserin hydrochloride BIMT-17 hydrochloride; BIMT-17BS hydrochloride	5-HT Receptor	Neurological Disease Cancer
Flibanserin (BIMT-17; BIMT-17BS) hydrochloride is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with K_i values of 1 nM and 49 nM, respectively. Flibanserin hydrochloride binds to dopamine D4 receptors with an K_i value of 4-24 nM. Flibanserin hydrochloride shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research ^- .

HY-14340

WAY-181187 SAX-187	5-HT Receptor	Neurological Disease
WAY-181187 (SAX-187) is a potent and selective full 5-HT6 receptor agonist with a K_i of 2.2 nM and an EC₅₀ of 6.6 nM . WAY181187 mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist .

HY-110366

WAY-181187 oxalate SAX-187 oxalate	5-HT Receptor	Neurological Disease
WAY-181187 (SAX-187) oxalate is a potent and selective full 5-HT6 receptor agonist with a K_i of 2.2 nM and an EC₅₀ of 6.6 nM. WAY-181187 oxalate mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist .

HY-W746031

WAY-181187 hydrochloride SAX-187 hydrochloride	5-HT Receptor	Neurological Disease
WAY-181187 (SAX-187) hydrochloride is a potent and selective full 5-HT6 receptor agonist with a K_i of 2.2 nM and an EC₅₀ of 6.6 nM . WAY-181187 hydrochloride mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist .

HY-155318A

GPR3 agonist-2

Others Endocrinology

GPR3 agonist-2(compound 32) is a potent full agonist of G protein-coupled receptor 3, with the IC₅₀of 260 nM .

HY-14558

Tandospirone 2 Publications Verification SM-3997	5-HT Receptor	Neurological Disease
Tandospirone (SM-3997) is a potent and selective 5-HT_1A receptor partial agonist, with a K_i of 27 nM. Tandospirone has anxiolytic and antidepressant activities. Tandospirone can be used for the research of the central nervous system disorders and the underlying mechanisms .

HY-110053

Tandospirone hydrochloride SM-3997 hydrochloride	5-HT Receptor	Neurological Disease
Tandospirone (SM-3997) hydrochloride is a potent and selective 5-HT_1A receptor partial agonist, with a K_i of 27 nM. Tandospirone hydrochloride has anxiolytic and antidepressant activities. Tandospirone hydrochloride can be used for the research of the central nervous system disorders and the underlying mechanisms .

HY-153548

P2X2/3 modulator-1	P2X Receptor	Neurological Disease Inflammation/Immunology
P2X2/3 modulator-1 (Compound 46) is a P2X2/3 modulator. P2X2/3 modulator-1 can be used in the study of pain, central nervous system disorders and inflammation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0193

Prazosin 5+ Cited Publications	Classification of Application Fields Disease Research Fields Endocrinology	Adrenergic Receptor
Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder.

Cat. No.	Product Name	Chemical Structure

HY-B0161S

Duloxetine-d7
Duloxetine-d₇ ((S)-Duloxetine-d₇) is the deuterium labeled Duloxetine. Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD)[1][2].

HY-B0193S

Prazosin-d8
Prazosin-d₈ is the deuterium labeled Prazosin. Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder.

HY-B0161AS

Duloxetine D3 hydrochloride
Duloxetine-d₃ (hydrochloride) is a deuterium labeled Duloxetine hydrochloride. Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD)[1][2].

HY-B1115S

Buspirone-d8 hydrochloride
Buspirone-d₈ (hydrochloride) is the deuterium labeled Buspirone hydrochloride. Buspirone hydrochloride is an anxiolytic psychotropic agent, is used to treat generalized anxiety disorder (GAD).

HY-B0548AS2

Hydroxyzine-d8 dihydrochloride
Hydroxyzine-d₈ (dihydrochloride) is the deuterium labeled Hydroxyzine dihydrochloride. Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder[1][2].

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anxiety disorders

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